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The culmination of all of these studies come to light with the finding of several (some reported and many from our group still publication pending) Larons Syndrome (congenital IGF-1 deficiency or GH insensitivity) never treated patients who underwent progression to MetS and ultimately to T2D together with diabetic retinopathy when they reached their late 30 s, [250, 251]

doi:10.1097/HJR.0b013e32828622d7 Sasaninia K, Kelley M, Abnousian A, et al

PMID: 20721598

Laboratory research has documented interactions with vascular endothelial growth factor (VEGF) and related growth factors involved in angiogenesis, the formation of new blood vessels, making this a significant area of interest in regenerative research